Replication of Bone Marrow Differentiation Niche: Comparative Evaluation of Different Three‐Dimensional Matrices

• DOI: 10.1002/smll.201202133
• Publication Date: 2012-12-22T04:56:38Z
• Authors: Meghan J. Cuddihy; Yichun Wang; Charles Machi; Joong Hwan Bahng; Nicholas A. Kotov
• Keywords: Scaffolds; 0303 health sciences; Tissue Engineering; Tissue Scaffolds; Stem Cells; Physics; Science; Bone Marrow Cells; Cell Differentiation; Hydrogels; Cell Line; 03 medical and health sciences; Engineering; Bone Marrow; Materials Science and Engineering; Humans; Stem Cell Niche

The comparative evaluation of different 3D matrices-Matrigel, Puramatrix, and inverted colloidal crystal (ICC) scaffolds-provides a perspective for studying the pathology and potential cures for many blood and bone marrow diseases, and further proves the significance of 3D cultures with direct cell-cell contacts for in vitro mimicry of the human stem cell niche.