Three Dimensional, Sheathless, and High‐Throughput Microparticle Inertial Focusing Through Geometry‐Induced Secondary Flows

• DOI: 10.1002/smll.201202413
• Publication Date: 2012-11-12T11:50:11Z
• Authors: Aram J. Chung; Daniel R. Gossett; Dino Di Carlo
• Keywords: Microparticle

A novel inertial focusing platform creates a single-stream microparticle train in single-focal plane without sheath fluids and external forces, all high-throughput manner. The proposed design consists of low-aspect-ratio straight channel interspersed with series constrictions height arranged orthogonally, making use geometry-induced secondary flows. Focusing efficiency as high 99.77% is demonstrated throughput 36 000 particles s−1 for variety different sized cells.