Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo

• DOI: 10.1002/smll.201703306
• Publication Date: 2017-12-05T10:39:54Z
• Authors: Chao Zhang; Zunfeng Liu; Ying Zheng; Yadi Geng; Chao Han; Yamin Shi; Hongbin Sun; Can Zhang; Yijun Chen; Luyong Zhang; Qinglong Guo; Lei Yang; Xiang Zhou; Lingyi Kong
• Keywords: Nanocarriers

Abstract Mitochondria‐mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell‐suicide factors in mitochondria, however, low permeability mitochondria bottleneck targeting drug delivery. In this paper, glycyrrhetinic acid (GA), natural product from Glycyrrhiza glabra , found be novel ligand, which can improve mitochondrial and enhance uptake mitochondria. GA‐functionalized graphene oxide (GO) prepared used as an effective carrier targeted delivery doxorubicin into The detailed vitro vivo mechanism study shows that GO causes decrease membrane potential activates MMA pathway. system demonstrates highly improved induction ability anticancer efficacy compared non‐GA‐functionalized nanocarrier system. also toxicity, suggesting it useful tool