A Mussel‐Inspired Persistent ROS‐Scavenging, Electroactive, and Osteoinductive Scaffold Based on Electrochemical‐Driven In Situ Nanoassembly

• DOI: 10.1002/smll.201805440
• Publication Date: 2019-05-20T09:39:03Z
• Authors: Ting Zhou; Liwei Yan; Chaoming Xie; Pengfei Li; Lili Jiang; Ju Fang; Cancan Zhao; Fuzeng Ren; Kefeng Wang; Yingbo Wang; Hongping Zhang; Tailin Guo; Xiong Lu
• Keywords: Scavenging

Conductive polymers are promising for bone regeneration because they can regulate cell behavior through electrical stimulation; moreover, antioxidative agents that be used to protect cells and tissues from damage originating reactive oxygen species (ROS). However, conductive lack affinity osteoinductivity, which limits their application in tissue engineering. Herein, an electroactive, affinitive, persistent ROS-scavenging, osteoinductive porous Ti scaffold is prepared by the on-surface situ assembly of a polypyrrole-polydopamine-hydroxyapatite (PPy-PDA-HA) film layer-by-layer pulse electrodeposition (LBL-PED) method. During LBL-PED, PPy-PDA nanoparticles (NPs) HA NPs synthesized uniformly coated on inside outside. PDA entangled with doped into PPy enhance ROS scavenging rate realize repeatable, efficient over long period time. stimulation synergistically promote osteogenic differentiation PPy-PDA-HA films. Ultimately, provides excellent synergistic effects electroactivity, affinity, activity osteoinductivity NPs. This study new strategy functionalizing scaffolds show great promise as implants regeneration.