Single Cell Analysis: Label‐Free Optofluidic Nanobiosensor Enables Real‐Time Analysis of Single‐Cell Cytokine Secretion (Small 26/2018)

• DOI: 10.1002/smll.201870119
• Publication Date: 2018-06-27T13:37:33Z
• Authors: Xiaokang Li; Maria Soler; Crispin Szydzik; Khashayar Khoshma...; Julien Schmidt; George Coukos; Arnan Mitchell; Hatice Altug
• Keywords: Single-Cell Analysis

Dynamic monitoring and analysis of protein secretion from single cells remain challenges. In article number 1800698, Hatice Altug co-workers present an optofluidic nanoplasmonic biosensor for real-time cytokine secretion. The label-free system enables the detection quantification secretions while maintaining controlled conditions cell activity. With integration into multifunctional microfluidic systems, this can be a powerful tool to characterize single-cell signaling basic clinical research.