Lipophilic NO‐Driven Nanomotors as Drug Balloon Coating for the Treatment of Atherosclerosis

• DOI: 10.1002/smll.202203238
• Publication Date: 2022-08-13T02:46:08Z
• Authors: Xueting Tang; Lin Chen; Ziyu Wu; Yazhou Li; Jiaqi Zeng; Wentao Jiang; Wenzhi Lv; Mimi Wan; Chun Mao; Min Zhou
• Keywords: Intimal hyperplasia

Abstract Drug‐coated balloons (DCB) intervention is an important approach for the treatment of atherosclerosis (AS). However, this therapeutic has drawbacks poor drug retention and penetration at lesion site. Here, a lipophilic drug‐loaded nanomotor as modified balloon coating AS reported. First, PMA‐TPP/PTX loaded with PTX triphenylphosphine (TPP) compounds synthesized. The nanomotors use nitric oxide (NO) driving force, which produced from reaction between arginine on motor substrate excess reactive oxygen species (ROS) inducible synthase (iNOS) in microenvironment. final vitro vivo experimental results confirm that introduction technology can greatly enhance permeability atherosclerotic lesions. In particular, NO also play anti‐AS role improving endothelial cell function reducing oxidative stress. chemotherapeutic onto inhibit division proliferation, thereby exerting effect inhibiting vascular intimal hyperplasia, helpful multiple therapies AS. Using to solve cardiovascular diseases may be promising research direction.