Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery

• DOI: 10.1002/smtd.202301664
• Publication Date: 2024-04-28T14:53:54Z
• Authors: Qian Xiao; Lingling Shang; Yang Peng; Ludan Zhang; Yanze Wei; Decai Zhao; Yasong Zhao; Jiawei Wan; Yuguang Wang; Dan Wang
• Keywords: Biocompatibility; Rational design; Cancer Therapy; Biocompatible material

Abstract Multifunctional drug delivery systems (DDS) are in high demand for effectively targeting specific cells, necessitating excellent biocompatibility, precise release mechanisms, and sustained capabilities. The hollow multishelled structure (HoMS) presents a promising solution, integrating structural compositional design efficient DDS development amidst complex cellular environments. Herein, starting from Fe‐based metal‐organic framework (MOF), amorphous coordination polymers (CP) composited HoMS with controlled shell numbers fabricated by balancing the rate of MOF decomposition formation. Fe‐CP loaded DOX is utilized synergistic chemotherapy chemodynamic therapy, offering responsive capability (excellent pH‐triggered 82% within 72 h at pH 5.0 solution doxorubicin (DOX) loading capacity 284 mg g −1 ). In addition to its potent attributes, Fe‐CP‐HoMS possesses therapy potential continuously catalyzing H 2 O generate ·OH species cancer thus inhibiting cell proliferation. DOX@3S‐Fe‐CP‐HoMS, concentration 12.5 µg mL , demonstrates significant inhibitory effects on cells while maintaining minimal cytotoxicity toward normal cells. It envisioned that CP‐HoMS could serve as an effective biocompatible platform advancement intelligent realm therapy.