Subventricular Zone Localized Irradiation Affects the Generation of Proliferating Neural Precursor Cells and the Migration of Neuroblasts

• DOI: 10.1002/stem.1214
• Publication Date: 2012-09-04T15:28:01Z
• Authors: Pragathi Achanta; Vivian Capilla‐Go...; David Purger; Juvenal Reyes; Kurt Sailor; Hongjun Song; Jose Manuel Garci...; Oscar Gonzalez‐Perez; Eric Ford; Alfredo Quinones‐...
• Keywords: Neuroblast; Rostral migratory stream

Radiation therapy is a part of the standard treatment for brain tumor patients, often resulting in irreversible neuropsychological deficits. These deficits may be due to permanent damage neural stem cell (NSC) niche, local progenitors, or neurotoxicity. Using computed tomography-guided localized radiation technique, we studied effects on NSC proliferation and neuroblast migration mouse brain. Localized irradiation subventricular zone (SVZ) eliminated proliferating precursor cells migrating neuroblasts. After irradiation, type B SVZ lacked ability generate Neuroblasts from unirradiated posterior did not follow their normal migratory path through irradiated anterior SVZ. Our results indicate that neuroblasts were replenished, despite presence post-irradiation. This study provides novel insights into neurogenesis potentially lead development new radiotherapy strategies minimize NSCs migration.