Astrocytic Adenosine 5′-Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus

• DOI: 10.1002/stem.1408
• Publication Date: 2013-04-30T09:12:15Z
• Authors: Xiong Cao; Liang-Ping Li; Xi-He Qin; Shu-Ji Li; Meng Zhang; Qian Wang; Hong-Hai Hu; Ying-Ying Fang; Yu-Bo Gao; Xiao-Wen Li; Li-Rong Sun; Wen-Chao Xiong; Tian-Ming Gao; Xin-Hong Zhu
• Keywords: Purinergic Signalling; Adenosine triphosphate

Abstract Astrocytes are key components of the niche for neural stem cells (NSCs) in adult hippocampus and play a vital role regulating NSC proliferation differentiation. However, exact molecular mechanisms by which astrocytes modulate have not been identified. Here, we identified adenosine 5′-triphosphate (ATP) as proliferative factor required astrocyte-mediated NSCs hippocampus. Our results indicate that ATP is necessary sufficient to promote vitro. The lack inositol 1,4,5-trisphosphate receptor type 2 transgenic blockage vesicular gliotransmission induced deficient release from astrocytes. This deficiency led dysfunction could be rescued via administration exogenous ATP. Moreover, P2Y1-mediated purinergic signaling involved astrocyte promotion proliferation. As hippocampal neurogenesis potentially major mood disorder, our might offer mechanistic insights into this disease.