Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A First-in-Man Trial in 35 Patients

• DOI: 10.1002/stem.2657
• Publication Date: 2017-06-10T08:36:41Z
• Authors: Tommy S. de Windt; Lucienne A. Vonk; Ineke C. M. Slape...; Razmara Nizak; Mattie H. P. van ...; Daniel B. F. Saris
• Keywords: Hyaline cartilage; Regenerative Medicine

Abstract MSCs are known as multipotent mesenchymal stem cells that have been found capable of differentiating into various lineages including cartilage. However, recent studies suggest pericytes stimulate tissue repair through trophic signaling. Aimed at articular cartilage in a one-stage cell transplantation, this study provides first clinical evidence autologous the knee without engrafting host tissue. A phase I (first-in-man) trial studied application allogeneic mixed with 10% or 20% recycled defect derived chondrons for treatment defects 35 patients. No treatment-related serious adverse events were and statistically significant improvement outcome shown. Magnetic resonance imaging second-look arthroscopies showed consistent newly formed biopsy taken from center was to hyaline-like features high concentration proteoglycans type II collagen. DNA short tandem repeat analysis delivered unique proof regenerated contained patient-DNA only. These findings support hypothesis regenerative response. This first-in-man supports paradigm shift which applied augmentations “signaling cells” rather than opens doors other applications.