Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model

• DOI: 10.1002/term.1497
• Publication Date: 2012-06-08T10:54:10Z
• Authors: Cheryl V. Rahman; Dror Ben-David; Amritpaul Dhillon; Gisela Kuhn; Toby W. A. Gould; Ralph Müller; Felicity R. A. J....; Kevin M. Shakesheff; Erella Livne
• Keywords: Mice; 0303 health sciences; 03 medical and health sciences; Tissue Scaffolds; Microscopy, Electron, Scanning; Animals; Bone Morphogenetic Protein 2; Cell Line; 12. Responsible consumption

Sustained and controlled delivery of growth factors, such as bone morphogenetic protein 2 (BMP-2), from polymer scaffolds has excellent potential for enhancing regeneration. The present study investigated the use novel sintered prepared using temperature-sensitive PLGA/PEG particles. Growth factors can be incorporated into these by mixing reconstituted factor with particles prior to sintering. ability deliver BMP-2 in a sustained manner was assessed osteogenic determined mouse calvarial defect model. released vitro over 3 weeks. On average, ca. 70% loaded end this time period. shown active induce osteogenesis when used cell culture assay. A substantial increase new volume 55% observed model BMP-2-loaded compared empty controls. An 31% without BMP-2, These results demonstrate bone-regeneration applications.