Toxicological evaluation of silver nanoparticles and silver nitrate in rats following 28 days of repeated oral exposure

• DOI: 10.1002/tox.22263
• Publication Date: 2016-03-21T17:50:36Z
• Authors: Guangqiu Qin; Song Tang; Shibin Li; Haoliang Lu; Yanwu Wang; Peng Zhao; Bin Li; Jiehong Zhang; Liang Peng
• Keywords: Silver nanoparticle; Silver nitrate; White blood cell

The increasing application of silver nanoparticles (AgNPs) has been raising concerns about their potential adverse effects to human and the environment. However, knowledge on systemic toxicity AgNPs in mammalian systems is still limited. present study investigated PVP-coated rats treated with repeated oral administration, compared that equivalent dose AgNO3 . Specifically, one hundred male female were orally administrated particulate or ionic forms (Ag) separately at doses 0.5 1 mg kg-1 body weight daily for 28 days. results reveal no significant toxic up weight, respect organ food intake, histopathological examination. Ag distribution pattern organs was similar rats, showing liver kidneys are main target followed by testis spleen. total contents significantly lower than those rats. comparisons between treatments further indicated more potent biochemical hematological parameters including red blood cell count (RBC), platelet (PLT), white (WBC) aspartate transaminase (AST). Results this suggested least partially contributed observed AgNPs, both should be taken into consideration toxicological evaluation AgNPs. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 609-618, 2017.