Reproductive toxicity induced by nickel nanoparticles in Caenorhabditis elegans

• DOI: 10.1002/tox.22373
• Publication Date: 2016-10-17T13:18:51Z
• Authors: Lu Kong; Xiaojie Gao; Jiaqian Zhu; Ting Zhang; Yuying Xue; Meng Tang
• Keywords: Reproductive toxicity; Reproductive system

ABSTRACT To investigate the reproductive toxicity and underlying mechanism of nickel nanoparticles (Ni NPs), Caenorhabditis elegans ( C. ) were treated with/without 1.0, 2.5, 5.0 μg cm −2 Ni NPs or microparticles MPs). Generation time, fertilized egg numbers, spermatide activation motility detected. Results indicated, under same treatment doses, that induced higher to than MPs. Reproductive toxicities observed in included a decrease brood size, activation, but an increase generation time out‐of‐round spermatids. The on may be by oxidative stress. is consistent with our previous results rats. Therefore, can used as alternative model detect early exposure. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1530–1538, 2017.