Protective effects of trehalose against Mn‐induced α‐synuclein oligomerization in mice: Involvement of oxidative stress and autophagy

• DOI: 10.1002/tox.22842
• Publication Date: 2019-09-09T11:34:05Z
• Authors: Meng‐Jiao Jing; Kuan Liu; Chang Liu; Dong‐Ying Yan; Zhuo Ma; Can Wang; Yu Deng; Wei Liu; Bin Xu
• Keywords: Cell damage

Abstract Overexposure to manganese (Mn) is widely known induce alpha‐synuclein (α‐Syn) oligomerization, which has been attributed the oxidative damage of α‐Syn protein. Trehalose shown autophagy and serve as a chemical chaperone, but little information reported about its effect on Mn‐induced oligomerization. In this study, we investigate whether trehalose can effectively interfere with using different concentrations (2% 4% (g/vol [mL])) in mouse model manganism. After 6 weeks exposure Mn, both stress were activated resulted oligomerization neuronal cell brain tissue. Our results also revealed that pretreatment significantly reduced protein increased activation. These findings clearly demonstrated relieve through anti‐oxidative autophagy‐inducing effects.