Nanog mediates tobacco smoke‐induced enhancement of renal cancer stem cell properties

• DOI: 10.1002/tox.22992
• Publication Date: 2020-07-10T13:32:06Z
• Authors: Taotao Zhang; Hongliang Sun; Rui Liu; Wanshuang Cao; Tao Zhang; Enlai Li; Xianchao Sun; Wangyu Wu; Dexin Yu; Caiyun Zhong
• Keywords: Homeobox protein NANOG; Tobacco smoke

Nanog plays an important role in the regulation of cancer stem cells (CSCs) which participate tumorgenesis and progression. In renal cancer, tobacco smoke (TS) is considered a major risk factor. However, molecular mechanism by TS induces development CSC properties remains largely unknown. this study, we showed that level was elevated cell carcinoma (RCC) patients with smoking history, overexpression promoted traits CSCs cancer. We further demonstrated 8-week exposure enhanced formation tumorspheres, increased population CD133-positive cells, stimulated expression markers. addition, found to play accelerating growth transition from G1 S phase CSCs. Finally, TS-induced effects could be reversed through downregulation Nanog. Our results suggested mediating properties. This study may provide new insights into TS-related tumorigenesis, can contribute future therapeutics for