Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis

• DOI: 10.1002/tox.23378
• Publication Date: 2021-09-27T22:22:05Z
• Authors: Siyu Li; Bing Han; Pengfei Wu; Qingyue Yang; Xiaoqiao Wang; Jiayi Li; Yuge Liao; Ning Deng; Huijie Jiang; Zhigang Zhang
• Keywords: Immunosuppression; Reproductive system; Reproductive toxicity; Intraperitoneal injection; Mercury

Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through food chain. However, it is unknown that detailed mechanism of reproductive disorder induced by inorganic mercury male mice to date. This study investigated toxicological effect mercuric chloride (HgCl2 ) exposure on system mice. Male Kunming received normal saline daily or HgCl2 (3 mg/kg bodyweight) intraperitoneal injection for week. The function was evaluated, decline sperm quality, pregnancy rate, mean litter size, survival rate. Notably, we firstly found -induced immunosuppression fibrosis testis according results RNA sequencing. Collectively, these findings demonstrate disrupts induces testicular via inhibition CD74 signaling pathway