Autonomic behavioral impairment induced by simazine exposure during early life of male mouse is mediated by Lmx1a/Wnt1 pathway

• DOI: 10.1002/tox.23442
• Publication Date: 2021-12-22T16:25:56Z
• Authors: Xueting Li; Xiaomeng Hu; Yujia Jiang; Dandan Wang; Ting Wang; Baixiang Li
• Keywords: Simazine; Neurotoxicity

Simazine is a widely used herbicide and known as an environmental estrogen. Multiple studies have proved simazine can induced the degeneration of dopaminergic neuron resulting in degenerative disease-like syndrome. Herein, we explored neurotoxicity on nervous system embryos weaned offspring during maternal gestation period or lactation periods. We found that disturbed crucial components expression involved Lmx1a/Wnt1 pathway embryonic offspring. Furthermore, morphological behavioral tests performed male treated by suggested grip strength, autonomic exploring, space sense ability were weakened, well pathological damage was clearly observed. But, same less significantly observed female Our findings will provide reliable reference for determination limits new insight into pathogenesis nonfamilial neurodegenerative diseases related to risk factors.