circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F6

• DOI: 10.1002/tox.23498
• Publication Date: 2022-02-28T09:33:30Z
• Authors: Shu‐Lan Gao; Ying Fan; Xiao‐Dan Liu; Wei Liu; Man Zhao
• Keywords: MTT assay

The role of circ_0089153 in breast cancer (BCa) malignancy development was explored. expression BCa analyzed by Gene Expression Omnibus database. Clinical tissues were obtained from 90 patients. Cell counting kit-8 assay, 5-ethnyl-2 deoxyuridine assay and colony formation experiment applied for proliferation detection. Wound healing Transwell used migration invasion Dual luciferase reporter gene RNA immunoprecipitation pull-down conducted. In vivo growth metastasis cells performed. Quantitative real-time polymerase chain reaction, Western blot immunohistochemistry RNAs proteins expression. up-modulated indicated an unfavorable survival knockdown attenuated proliferation, migration, epithelial-mesenchymal transition (EMT) (P < .01). miR-2467-3p sponge. Low a worse overexpression reduced EMT .05). enhanced sponging E2F6 directly suppressed miR-2467-3p. high patients associated with survival. lung oncogene cancer, which through miR-2467-3p/E2F6. suggested to be potential target treatment.