Inhibition of the Nrf2 signaling pathway involved in imidacloprid‐induced liver fibrosis in Coturnix japonica

• DOI: 10.1002/tox.23601
• Publication Date: 2022-06-18T09:00:34Z
• Authors: Ning Deng; Yueying Lv; Qizheng Bing; Siyu Li; Bing Han; Huijie Jiang; Qingyue Yang; Xiaoqiao Wang; Pengfei Wu; Yan Liu; Zhigang Zhang
• Keywords: Fipronil

Abstract Imidacloprid (IMI) is a kind of widely used neonicotinoid insecticide. However, the toxicity IMI not only applied to target pests but also causes serious negative effects on birds and other creatures. Our previous studies have shown that long‐term exposure can induce liver fibrosis in quails. specific mechanism quail induced by completely clear. Accordingly, purpose this study further clarify potential molecular IMI‐induced Japanese quails ( Coturnix japonica ) were treated with/without (intragastric administration with 6 mg/kg body weight) presence/absence luteolin (Lut) (fed 800 mg/kg) for 90 days. The results reveal hepatic fibrosis, oxidative stress, fatty degeneration, inflammation, down‐expression nuclear factor‐E2‐related factor‐2 (Nrf2). Furthermore, treatment Lut, Nrf2 activator, increased expression livers alleviated Altogether, our demonstrates inhibition pathway key These provide new understanding practical basis caused IMI.