RETRACTED: Zinc finger Protein207 orchestrates glioma migration through regulation of epithelial‐mesenchymal transition

• DOI: 10.1002/tox.24271
• Publication Date: 2024-04-09T12:01:48Z
• Authors: Chao Zhao; Yuduo Guo; Yujia Chen; Guanjie Shang; Dixiang Song; Jun Wang; Jingjing Yang; Hongwei Zhang
• Keywords: Human Protein Atlas

Abstract Background Glioma represents the predominant primary malignant brain tumor. For several years, molecular profiling has been instrumental in management and therapeutic stratification of glioma, providing a deeper understanding its biological complexity. Accumulating evidence unveils putative involvement zinc finger proteins (ZNFs) cancer. This study aimed to elucidate role significance ZNF207 glioma. Methods Utilizing online data such as The Cancer Genome Atlas (TCGA), Chinese (CGGA), Genotype‐Tissue Expression (GTEx) project, Clinical Proteomic Tumor Analysis Consortium (CPTAC), Human Protein (HPA) databases, conjunction with bioinformatics methodologies including GO, KEGG, GSEA, CIBERSORT immune cell infiltration estimation, protein–protein interaction (PPI) analysis, enabled comprehensive exploration ZNF207's gliomagenesis. Immunohistochemistry RT‐PCR techniques were employed validate expression level glioma samples. Subsequently, effects on cells explored through vitro assays. Results Our results demonstrate elevated gliomas, correlating unfavorable patient outcomes. Stratification analyses used delineate prognostic efficacy different clinicopathological characteristics. Immunocorrelation analysis revealed significant association between levels T helper cells, macrophages, natural killer (NK) cells. clinical features, we constructed an OS prediction model displayed well discrimination C‐index 0.861. Moreover, strategic silencing attenuated advancement, evidenced by diminished cellular proliferation, weakened tumorigenesis, augmented apoptotic activity, curtailed migratory capacity alongside inhibition epithelial‐mesenchymal transition (EMT) pathway. Conclusions may identify prospective biomarker candidate for prevention, valuable insights into pathogenesis treatment strategies.