Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High‐Fat Dietary Habit

• DOI: 10.1002/tox.24499
• Publication Date: 2025-02-21T09:18:36Z
• Authors: Yi‐Ling Lin; Christoper Caesar...; Yi‐Feng Kao; Jung‐Kai Tseng; Yi‐Chen Chen
• Keywords: Steatosis

ABSTRACT The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges. This study explored ameliorative effects Ophiocordyceps sinensis mycelia (TCM‐NA01 formula: 1.4 mg adenosine 55.2 polysaccharide/capsule) on hepatosteatosis development a high‐fat diet (HFD)‐fed mice. TCM‐NA01 supplementation significantly reduced ( p < 0.05) body weight, adipose tissue, serum triglyceride (TG)/cholesterol (TC), aspartate aminotransferase (AST), alanine (ALT), TG/TC levels HFD‐fed Increased fecal‐lipid bile‐acid outputs were observed. Apparent reductions lipid‐droplet steatosis scores mice supplemented TCM‐NA01. Furthermore, modulated lipid metabolism by decreasing acid synthesis promoting β‐oxidation. also enhanced antioxidant capacity decreased proinflammatory cytokines 0.05). These findings underscore potential O. as nutraceutical agent for alleviating hepatosteatosis, oxidative stress, chronic inflammation, offering promising strategy management NAFLD.