Effect of 17‐alpha hydroxyprogesterone caproate on cervical length in twin pregnancies

• DOI: 10.1002/uog.11174
• Publication Date: 2012-09-25T19:24:06Z
• Authors: A. C. Lim; E. Schuit; D. Papatsonis; J. van Eyck; M. M. Porath; C. M. van Oirschot; P. Hummel; T. H. M. Hasaart; G. Kleiverda; I. M. de Graaf; A. A. van Ginkel; B. W. J. Mol; H. W. Bruinse
• Keywords: Twin Pregnancy

Abstract Objectives Previous studies on singleton pregnancies have indicated that progestogens may reduce the rate of cervical shortening during pregnancy. The aim this study was to investigate whether treatment with 17‐alpha hydroxyprogesterone caproate (17‐OHPC) has an effect in twin pregnancies. Methods This a secondary analysis patients who had participated multicenter randomized clinical trial effectiveness 17‐OHPC preventing preterm birth multiple (the AMPHIA‐trial). We included all participants gestation undergone repeat length measurements performed separate women centers where standard protocol for both group and placebo analyzed using linear mixed model. Results Of 671 trial, 282 (42%) pregnancy underwent two or more measurements. these women, 140 were monitored protocol. observed overall reduction from 44.3 mm at 14–18 weeks 30.0 30–34 weeks' gestation. In group, decreased by 1.04 each gestational week, while 1.11 per week ( P = 0.6). For 10% decrease led increase risk (hazard ratio, 1.14; 95% CI, 1.08–1.21). Conclusion pregnancy, there is progressive cervix regardless use. Copyright © 2012 ISUOG. Published John Wiley & Sons, Ltd.