Severe second-trimester obstructive ventriculomegaly related to disorders of diencephalic, mesencephalic and rhombencephalic differentiation

• DOI: 10.1002/uog.12427
• Publication Date: 2013-02-01T15:37:57Z
• Authors: M. Cagneaux; A. Vasiljevic; M. Massoud; F. Allias; J. Massardier; P. Gaucherand; L. Guibaud
• Keywords: Ventriculomegaly; Diencephalon; Cerebral aqueduct; Cerebellar hypoplasia (non-human); Fourth ventricle; Lateral ventricles

By review of a series cases, we set out to identify sonographic features suggestive an obstructive mechanism in second-trimester fetuses with ventriculomegaly and describe developmental disorders related pathological differentiation the diencephalon, mesencephalon rhombencephalon that lead obstruction cerebrospinal fluid flow. We studied retrospectively 11 referred for severe undetermined origin. Neurosonography was performed detailed analysis third ventricle, thalami, cerebral aqueduct cerebellum. The imaging data were compared neuropathological eight patients, focus on level etiology obstruction. Parenchymal thinning reduction pericerebral spaces highly due mechanism. diencephalosynapsis (thalamic fusion ventricle atresia) five cases partial/complete stenosis six; it associated cerebellar hypoplasia six including rhombencephalosynapsis two cases. In nine present. isolated which are mechanism, close examination Sylvius cerebellum may reveal or rhombencephalon, often combination.