Prenatal unilateral cerebellar hypoplasia in a series of 26 cases: significance and implications for prenatal diagnosis

• DOI: 10.1002/uog.13217
• Publication Date: 2013-10-15T16:03:52Z
• Authors: M. Massoud; M. Cagneaux; C. Garel; N. Varene; M.‐L. Moutard; T. Billette; A. Benezit; C. Rougeot; J.‐M. Jouannic; J. Massardier; P. Gaucherand; V. Desportes; L. Guibaud
• Keywords: Cerebellar hypoplasia (non-human); Etiology; Echogenicity

To define imaging patterns of unilateral cerebellar hypoplasia (UCH), discuss possible pathophysiological mechanisms and underline the etiology prognosis associated with these lesions.In this retrospective study we reviewed charts 26 fetuses diagnosed between 2003 2011 UCH, defined by asymmetrical hemispheres or without decreased transverse diameter. The review included analysis anatomy hemispheres, including foliation, borders parenchymal echogenicity, severity hypoplasia. Data from clinical biological work-up follow-up were obtained.Our series could be divided into two groups according to whether features changed progressively remained constant during follow-up. In Group 1 (n = 8), progression features, echogenic changes and/or hyposignal in T2*-weighted MR images highly suggestive ischemic/hemorrhagic insult. 2 18), follow-up; UCH was abnormal foliation three proven cases clastic lesions, a cystic lesion noted PHACE (posterior fossa anomalies, hemangioma, arterial cardiac abnormalities/aortic coarctation, eye abnormalities) syndrome and, remaining cases, unchanged, no pattern typical hemorrhage. 24 infant liveborn continued 23, for mean period 3 years. Among these, neurological complications identified seven (in one (at 46 months) six 16 35 2). surface loss hemisphere > 50% 19/24 vermis clearly normal appearance 19/24. Predisposing factors fetal vascular insult eight cases: maternal alcohol addiction, diabetes mellitus, congenital cytomegalovirus infection pathological placenta thrombotic vasculopathy infarctions.UCH is as focal cerebellum that may secondary hemorrhage ischemic insult, suggesting origin, particularly when reveals over time. also clue prenatal diagnosis syndrome. amount does not correlate poor prognosis. often outcome.