Single deepest vertical pocket or amniotic fluid index as evaluation test for predicting adverse pregnancy outcome (SAFE trial): a multicenter, open‐label, randomized controlled trial

• DOI: 10.1002/uog.14924
• Publication Date: 2015-06-19T13:31:32Z
• Authors: S. Kehl; A. Schelkle; A. Thomas; A. Puhl; K. Meqdad; B. Tuschy; S. Berlit; C. Weiss; C. Bayer; J. Heimrich; U. Dammer; E. Raabe; M. Winkler; F. Faschingbauer; M. W. Beckmann; M. Sütterlin
• Keywords: Amniotic fluid index; Cardiotocography; Labor Induction; Multicenter trial

ABSTRACT Objective To determine whether the amniotic fluid index (AFI) or single deepest vertical pocket (SDP) technique for estimating volume is superior predicting adverse pregnancy outcome. Methods This was a multicenter randomized controlled trial including 1052 pregnant women with term singleton across four hospitals in Germany. Women were assigned randomly, according to computer‐generated allocation sequence, AFI SDP measurement estimation of volume. Oligohydramnios defined as ≤ 5 cm absence measuring at least 2 × 1 cm. The diagnosis oligohydramnios followed by labor induction. primary outcome measure postpartum admission neonatal intensive care unit. Further parameters rates and induction (for without specific indication), mode delivery. Results Postpartum unit similar between groups (4.2% ( n = 21) vs 5.0% 25); relative risk (RR), 0.85 (95% CI, 0.48–1.50); P 0.57). In group, there more cases (9.8% 49) 2.2% 11); RR, 4.51 2.2–8.57); < 0.01) (12.7% 33) 3.6% 10); 3.50 1.76–6.96); than group. Moreover, an abnormal cardiotocography seen often group (32.3% 161) 26.2% 132); 1.23 1.02–1.50); 0.03). other measures not significantly different two groups. Conclusions Use method increased rate improving perinatal therefore favorable estimate volume, especially population many low‐risk pregnancies. Copyright © 2015 ISUOG. Published John Wiley & Sons Ltd.