Prenatal diagnosis of cobblestone lissencephaly associated with Walker–Warburg syndrome based on a specific sonographic pattern

• DOI: 10.1002/uog.15735
• Publication Date: 2015-08-28T11:09:58Z
• Authors: A. Lacalm; B. Nadaud; M. Massoud; A. Putoux; P. Gaucherand; L. Guibaud
• Keywords: Adult; Cobblestone Lissencephaly; Walker-Warburg Syndrome; Echoencephalography; Ultrasonography, Prenatal; Pregnancy Trimester, First; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Pregnancy Trimester, Second; Humans; Female

ABSTRACTWe report a specific sonographic cerebral pattern of cobblestone lissencephaly (CL) that has not been described previously. This pattern was encountered in four index cases and allowed prenatal diagnosis of CL associated with Walker–Warburg syndrome. The pattern included both an outer echogenic band with reduced pericerebral space, corresponding to an infra‐ and supratentorial extracortical layer of neuroglial overmigration on pathological examination, and a ‘Z’‐shaped appearance of the brainstem. This pattern was found as early as 14 weeks' gestation in one of our cases. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.