Comorbidity, poverty and social vulnerability as risk factors for mortality in pregnant women with confirmed SARS‐CoV‐2 infection: analysis of 13 062 positive pregnancies including 176 maternal deaths in Mexico

• DOI: 10.1002/uog.24797
• Publication Date: 2021-10-21T09:40:21Z
• Authors: J. Torres‐Torres; R. J. Martinez‐Po...; S. Espino‐y‐Sosa; G. Estrada‐Gutierrez; J. M. Solis‐Paredes; J. R. Villafan‐Be...; V. Medina‐Jimenez; A. J. Rodriguez‐M...; L. Rojas‐Zepeda; L. C. Poon
• Keywords: Adult; 2. Zero hunger; Social Vulnerability; 1. No poverty; COVID-19; Comorbidity; 3. Good health; Cohort Studies; 03 medical and health sciences; Maternal Mortality; 0302 clinical medicine; Pregnancy; Maternal Death; Humans; Premature Birth; Female; Prospective Studies; Pregnancy Complications, Infectious; Mexico; Poverty

Mortality in pregnancy due to coronavirus disease 2019 (COVID-19) is a current health priority developing countries. Identification of clinical and sociodemographic risk factors related mortality pregnant women with COVID-19 could guide public policy encourage such accept vaccination. We aimed evaluate the association comorbidities socioeconomic determinants COVID-19-related severe Mexico.This an ongoing nationwide prospective cohort study that includes all positive reverse-transcription quantitative polymerase chain reaction result for acute respiratory syndrome 2 (SARS-CoV-2) from Mexican National Registry Coronavirus. The primary outcome was maternal death COVID-19. characteristics explored using log-binomial regression model adjusted possible confounders.There were 176 (1.35%) deaths among 13 062 consecutive SARS-CoV-2-positive women. Maternal age, as continuous (adjusted relative (aRR), 1.08 (95% CI, 1.05-1.10)) or categorical variable, associated COVID-19; aged 35-39 years (aRR, 3.16 2.34-4.26)) 40 older 4.07 2.65-6.25)) had higher mortality, compared those < 35 years. Other pre-existing diabetes 2.66 1.65-4.27)), chronic hypertension 1.75 1.02-3.00)) obesity 2.15 1.46-3.17)). Very high social vulnerability 1.88 1.26-2.80)) 1.49 1.04-2.13)) increased while very low reduced 0.47 0.30-0.73)). Being poor extremely also 1.53 1.09-2.15) aRR, 1.83 1.32-2.53), respectively).This study, which comprises largest date, has confirmed advanced diabetes, hypertension, obesity, status are mortality. © 2021 International Society Ultrasound Obstetrics Gynecology.