OC25.01: Mathematical models for predicting endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness > 4.5 mm

• DOI: 10.1002/uog.7905
• Publication Date: 2010-11-24T15:35:29Z
• Authors: G. Opolskiene; P. Sladkevicius; L. I. Valentin
• Keywords: Power doppler; Uterine cavity

To build mathematical models for calculation of the individual risk endometrial malignancy in women with postmenopausal bleeding using clinical data, sonographic thickness and power Doppler results. Two hundred sixty one patients bleeding, > 4.5 mm no fluid uterine cavity were included. They underwent transvaginal two-dimensional gray scale ultrasound examination endometrium. The image showing most vascularised section through endometrium as assessed by was frozen, outlined, percentage area (vascularisation index) calculated computer software. A structured history taken to collect information. Multivariate logistic regression used create predict malignancy. There 63 (32%) malignant 198 benign endometria. When only a model including variables age, use warfarin hormonal replacement therapy (HRT) had largest (0.74) under receiver operating characteristic curve (AUC). Adding variables, AUC (0.82). vascularisation index thickness, HRT, (0.91). diagnostic performance predicting cancer increases substantially when adding information variables. best are likely be clinically useful but need prospectively validated.