Alzheimer's disease: Potential pathogenesis and imaging findings
0301 basic medicine
03 medical and health sciences
neuroimaging
Medical technology
magnetic resonance imaging
Alzheimer's disease
R855-855.5
TP248.13-248.65
positron emission computed tomography
Biotechnology
DOI:
10.1002/viw.20230025
Publication Date:
2023-05-25T13:34:45Z
AUTHORS (4)
ABSTRACT
AbstractAlzheimer's disease (AD) is a common neurodegenerative disease. The histopathological changes in AD include amyloid β‐protein (Aβ) deposition, tau tangles, neuroinflammation, and neurodegeneration. Some of the pathological changes could be shown in vivo by positron emission tomography (PET) and magnetic resonance imaging (MRI) biomarkers, which play a key role in diagnosing AD. Fluorodeoxyglucose positron emission tomography (FDG‐PET) can reflect and predict dysfunction. Aβ‐PET is sensitive for the diagnosis of early AD but cannot distinguish the severity of AD. Tau‐PET can compensate for the deficiency of Aβ‐PET. Tau tangles are positively correlated with the severity of AD and associated with cognitive impairment. Probes targeting neuroinflammation in AD have been developed, but further study is needed to validate their effectiveness. Conventional MRI performs high tissue contrast that can show structural changes and has been routinely applied in clinical practice, such as in the evaluation of cerebral atrophy. Advanced MRI sequences (such as diffusion tensor imaging, arterial spin labeling, magnetic resonance spectroscopy, blood oxygenation level dependent, and quantitative susceptibility mapping) can provide additional information beyond structure that includes brain microstructure, blood perfusion, metabolite concentration, brain activity, connections and networks between brain regions, iron deposition, etc. Integrated PET and MRI may improve the diagnostic efficiency of AD.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (98)
CITATIONS (14)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....