Pharmacokinetic‐pharmacodynamic integration of enrofloxacin and its metabolite ciprofloxacin in buffalo calves

• DOI: 10.1002/vms3.10
• Publication Date: 2015-11-27T03:37:59Z
• Authors: Prashant S. Daundkar; Bhaskar Vemu; Vinod K. Dumka; Suresh K. Sharma
• Keywords: Pharmacodynamics

Abstract The present study was planned with an objective to test the pharmacokinetics of a new formulation enrofloxacin (Flobac ® SA ) in buffalo calves. drug administered at dose rate 7.5 mg kg −1 body weight through intravenous (i.v.) and intramuscular (i.m.) route followed by plasma collection analysis different time intervals. After analysis, using High Performance Liquid Chromatography – Ultraviolet, various pharmacokinetic parameters were calculated visual fit for compartmental integration pharmacodynamic against Escherichia coli Pasteurella multocida . Although total area under concentration curve higher i.v. route, mean residence metabolic conversion ratio following administration i.m. indicating longer persistence body. Overall bioavailability parent compound its metabolite found be 91%. Upon, Pharmacokinetic–Pharmacodynamic integration, all indicated significant antibacterial activity. It can concluded that used contain infections caused P. E.