Assessment of Oxidative Stress Markers in Cats Undergoing Ovariohysterectomy by a Midline or Flank Approach

• DOI: 10.1002/vms3.70363
• Publication Date: 2025-05-05T14:08:51Z
• Authors: Zohreh Nazari; Mehrdad Mohri; Mohammad Heidarpour; Hossein Kazemi Me...

ABSTRACTObjectivesThe main goal of this study was to assess oxidative stress markers in cats that were having an ovariohysterectomy (OVH) using either a midline (MAG) or flank (FAG) method.MethodsTwelve entire female cats were randomly assigned into two groups and ovariohysterectomized by a midline (MAG) or flank approach (FAG). Clinical evaluation was performed and haematological and biomarkers of oxidative status were evaluated at baseline (before surgery), one, and 24 h after endotracheal extubation.ResultsConcerning cardiorespiratory parameters, there were no differences in heart rate (HR), respiratory rate (RR), rectal temperature (RT), peripheral capillary oxygen saturation (SpO2 saturation), and End‐tidal CO2 (ETCO2) values between groups or measured time during surgery. No significant differences were observed for the concentration of malondialdehyde (MDA), total antioxidant capacity (TAC), activities of erythrocyte glucose‐6‐phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx) and superoxide dismutase (SOD) between the two groups. There were also no significant differences between different sampling times in each group.Conclusions and relevanceResults of the present study showed that ovariohysterectomy (OVH), either by midline or flank approaches, was not associated with oxidative stress and lipid peroxidation in the studied cats up to 24 h after surgery.