Effects of angiotensin II receptor blockers in the coronary arteries of hypertensive rats: Analysis of elemental distribution using LEXRF

• DOI: 10.1002/xrs.3008
• Publication Date: 2019-01-24T08:02:40Z
• Authors: Arissa Pickler; Andrea Mantuano; Carla L. Mota; Tayane Tanure; Luanna Serqueira; Samara Ferreira‐M...; Cláudio S.C. Lau; Camila Salata; Carlos E. de Almeida; Alessandro Nascim...; Gabriela Sena; Gabriel Fidalgo; Marcos V. Colaço; Matteo Altissimo; Diana E. Bedolla; Alessandra Gianon...; Delson Braz; Regina C. Barroso
• Keywords: Olmesartan; Coronary arteries

Hypertension is one of the major public health problems worldwide. It can cause severely alterations in artery structure and function such as vascular remodeling. Angiotensin II (Ang II) has been linked to dysfunction. shown that blockade Ang type 1 receptor with an blocker (ARBs) may reverse pathology independently blood pressure lowering. There therefore a special interest establishing whether antihypertensive treatment correct part or completely structural functional arteries. Several studies have regression remodeling small arteries spontaneously hypertensive rats (SHR) treated ARBs agents. However, its efficiency was not verified at elemental level literature. Knowledge distribution tissues great importance study diseases, because chemical imbalance alter biological functions. Elemental semiquantitative microanalysis coronary normotensive, SHRs, SHRs (losartan olmesartan) performed using low energy X‐ray fluorescence maps acquired on TwinMic spectromicroscopy station, located Elettra synchrotron radiation facility. Morphological changes samples were also investigated. The results demonstrate despite agents used belong same class, their capacities revert caused by hypertension are different.