UNDERSTANDING INTERCELLULAR INTERACTIONS AND CELL ADHESION: LESSONS FROM STUDIES ON PROTEIN—METAL INTERACTIONS

• DOI: 10.1006/cbir.1997.0215
• Publication Date: 2002-10-06T22:25:04Z
• Authors: R. ECKERT; S. JENEY; J. K. H. HÖRBER
• Keywords: Protein Adsorption; Biomolecule

To understand cell—cell interactions and the of cells to non‐biological materials, studies on binding forces between cellular proteins material such as metal surfaces are essential. The adsorption solid—water interfaces is a multifactorial multistep process. First steps determined by long‐range where surface properties hydrophobicity, distribution charged groups, ion concentrations pH play important roles. In later structural rearrangements in protein molecule dehydration effects become more making process often irreversible. following we demonstrate that A tubulin have specific type interaction probably an intermediate step were attached tip microfabricated cantilever way only one interacts with surface. By recording force—distance curves atomic force microscope adhesion single molecules gold, titanium indium—tinoxid measured.