Molecular Characterization of the Klebicin B Plasmid of Klebsiella pneumoniae

Recombination, Genetic 0301 basic medicine 0303 health sciences Base Sequence Sequence Homology, Amino Acid Molecular Sequence Data Colicins Sequence Analysis, DNA 3. Good health Klebsiella pneumoniae 03 medical and health sciences Bacteriocins Multigene Family Sequence Homology, Nucleic Acid Escherichia coli Amino Acid Sequence Plasmids
DOI: 10.1006/plas.2001.1519 Publication Date: 2002-09-18T20:38:41Z
ABSTRACT
The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Klebsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebicin B protein is similar in sequence to the DNase pyocins and colicins, suggesting that klebicin B functions as a nonspecific endonuclease. The klebicin gene cluster, as well as the plasmid backbone, is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid maintenance functions and those of the colicin E1 plasmid suggest that pKlebB is a member of the ColE1 plasmid replication family.
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