Molecular Characterization of the Klebicin B Plasmid of Klebsiella pneumoniae
Recombination, Genetic
0301 basic medicine
0303 health sciences
Base Sequence
Sequence Homology, Amino Acid
Molecular Sequence Data
Colicins
Sequence Analysis, DNA
3. Good health
Klebsiella pneumoniae
03 medical and health sciences
Bacteriocins
Multigene Family
Sequence Homology, Nucleic Acid
Escherichia coli
Amino Acid Sequence
Plasmids
DOI:
10.1006/plas.2001.1519
Publication Date:
2002-09-18T20:38:41Z
AUTHORS (5)
ABSTRACT
The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Klebsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebicin B protein is similar in sequence to the DNase pyocins and colicins, suggesting that klebicin B functions as a nonspecific endonuclease. The klebicin gene cluster, as well as the plasmid backbone, is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid maintenance functions and those of the colicin E1 plasmid suggest that pKlebB is a member of the ColE1 plasmid replication family.
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CITATIONS (45)
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