Analysis of Protein–Glycosaminoglycan Interactions Using Traveling Wave Ion-Mobility Mass Spectrometry

Ion Mobility Spectrometry Proteins Mass Spectrometry Glycosaminoglycans
DOI: 10.1007/978-1-0716-1398-6_8 Publication Date: 2021-10-10T17:22:57Z
ABSTRACT
Traveling wave ion-mobility mass spectrometry (TWIMS) combined with native mass spectrometry (MS) has emerged as a powerful tool for analyzing biomolecules, including complexes of protein and heparan sulfate (HS). This technique allows determination of the stoichiometry of the protein-HS interaction and information on the overall 3D molecular envelope.
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