Patient-Derived Xenograft Models for Ovarian Cancer

• DOI: 10.1007/978-1-0716-3858-3_13
• Publication Date: 2024-04-27T11:01:52Z
• Authors: Trang Minh Tran; Gwo Yaw Ho; Simon Chu
• Keywords: Ovarian Neoplasms; Mice; Disease Models, Animal; Tumor Microenvironment; Humans; Animals; Heterografts; Female; Xenograft Model Antitumor Assays

Patient-derived xenograft (PDX) models play a crucial role for in vivo research. They maintain the original molecular characteristics of the human tumor and provide a more accurate tumor microenvironment, which cannot be replicated by in vitro models. This chapter describes four different transplantation methods, namely, intra-bursal, intrarenal capsule, intraperitoneal, and subcutaneous, to develop PDX models for ovarian cancer research.