Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren’s Syndrome

• DOI: 10.1007/978-1-4615-2417-5_105
• Publication Date: 2011-08-04T20:24:21Z
• Authors: M. G. Humphreys-B...; Y. Hu; Y. Nakagawa; P-L. Wang; K. R. Purushotham
• Keywords: Male; 2. Zero hunger; Mice, Inbred BALB C; Mice, Inbred Strains; Salivary Gland Diseases; 3. Good health; Disease Models, Animal; Mice; Diabetes Mellitus, Type 1; Sjogren's Syndrome; Mice, Inbred NOD; Hypergammaglobulinemia; Tears; Animals; Female; Saliva

Sjogren’s syndrome (S.S.) in the human patient population is an autoimmune inflammatory disease presenting clinical symptoms of xerophthalmia and xerostomia1. This condition predominantly affects women. Most diagnoses of S.S. is made in association with autoimmune connective tissue diseases such as rheumatoid arthritis or systemic lupus erythematosus.2 However, it can also be obseved as an isolated phenomenon, described as primary S.S.