Pre-Clinical Studies on Boron Neutron Capture Therapy

• DOI: 10.1007/978-1-4684-5622-6_13
• Publication Date: 2012-11-22T11:32:42Z
• Authors: Rolf F. Barth; Albert H. Soloway; Fazlul Alam; Nancy R. Clendenon; Thomas E. Blue; Naoki Mafune; Joseph H. Goodman; Wanda Gordon; Bhaskar Bapat; Dianne M. Adams; Alfred E. Staubus; Melvin J. Moeschb...; Reinhard Gahbauer; Allan J. Yates; Carl P. Boesel; Timothy F. Mengers; James F. Curran; Chris K. Wang; George E. Makroglou; Jone-Jiun Tzeng; Ralph G. Fairchild
• Keywords: Neutron capture; Isotopes of boron

The present report provides an overview of the multidisciplinary research effort on BNCT that currently is in progress at The Ohio State University. Areas under investigation include the preparation of boron containing monoclonal antibodies, the synthesis of boron containing derivatives of promazines and phathalocyanines, the development of a rat model for the treatment of glioblastoma by means of BNCT, the design of an accelerator-based neutron irradiation facility, and 10B concentration measurements using alpha track autoradiographic methods. Progress in each of these areas is described and the direction of future research is indicated.