The MULTICOM Protein Tertiary Structure Prediction System

• DOI: 10.1007/978-1-4939-0366-5_3
• Publication Date: 2014-02-26T12:52:04Z
• Authors: Jilong Li; Debswapna Bhattac...; Renzhi Cao; Badri Adhikari; Xin Deng; Jesse Eickholt; Jianlin Cheng
• Keywords: Structural genomics; Toolbox; Protein structure database; Protein Data Bank

With the expansion of genomics and proteomics data aided by the rapid progress of next-generation sequencing technologies, computational prediction of protein three-dimensional structure is an essential part of modern structural genomics initiatives. Prediction of protein structure through understanding of the theories behind protein sequence-structure relationship, however, remains one of the most challenging problems in contemporary life sciences. Here, we describe MULTICOM, a multi-level combination technique, intended to predict moderate- to high-resolution structure of a protein through a novel approach of combining multiple sources of complementary information derived from the experimentally solved protein structures in the Protein Data Bank. The MULTICOM web server is freely available at http://sysbio.rnet.missouri.edu/multicom_toolbox/.