Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer’s Disease

• DOI: 10.1007/978-1-4939-6598-4_28
• Publication Date: 2016-12-14T02:33:30Z
• Authors: Asami Kondo; Onder Albayram; Xiao Zhen Zhou; Kun Ping Lu
• Keywords: Mice, Knockout; NIMA-Interacting Peptidylprolyl Isomerase; Disease Models, Animal; Mice; Tauopathies; Alzheimer Disease; Behavior Rating Scale; Animals; tau Proteins; Immunohistochemistry; 3. Good health

Pin1 knockout in mice causes age-dependent neuropathy characterized by motor and behavioral deficits, tau hyper phosphorylation, tau filament formation, and neuronal degradation. Here, we describe the methods with mouse behavior test, immunostaining, and immunoblotting to detect many aspects of neurodegeneration in Pin1 knockout mice.