Methods for Measuring ctDNA in Lymphomas

• DOI: 10.1007/978-1-4939-8876-1_19
• Publication Date: 2018-10-22T07:26:54Z
• Authors: Davide Rossi; Adalgisa Condoluci; Valeria Spina; Gianluca Gaidano
• Keywords: Liquid biopsy; Minimal Residual Disease; Circulating tumor DNA; Cell-free fetal DNA

Plasma cell-free DNA (cfDNA) is an easily accessible source of tumor DNA that allows accurate profiling of lymphoma patients, representing a complementary source of tumor DNA to tissue biopsy for genotyping. Applications of cfDNA analysis in lymphomas include: (1) identification of tumor mutations in a biopsy-free manner; (2) tracking tumor clonal evolution and identification of mutations causing resistance to treatment; and (3) monitoring of residual disease after therapy.