Network-Based Drug Repositioning: Approaches, Resources, and Research Directions

• DOI: 10.1007/978-1-4939-8955-3_6
• Publication Date: 2018-12-13T11:21:36Z
• Authors: Salvatore Alaimo; Alfredo Pulvirenti
• Keywords: Drug repositioning; Drug-target interaction prediction; Interaction networks; Network-based drug repurposing; Precision medicine; Molecular Biology; Genetics; Gene Expression Regulation; Research; Drug Discovery; Drug Repositioning; Computational Biology; Humans; Gene Regulatory Networks; Precision Medicine; Ligands; Algorithms; 3. Good health

The wealth of knowledge and omic data available in drug research allowed the rising of several computational methods in drug discovery field yielding a novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning.