TRPML1-/TFEB-Dependent Regulation of Lysosomal Exocytosis

• DOI: 10.1007/978-1-4939-9018-4_12
• Publication Date: 2019-01-24T08:44:16Z
• Authors: Simone Di Paola; Diego L. Medina
• Keywords: TFEB; Lysosomal storage disease

Emerging experimental evidences indicate that the lysosome can trigger a calcium signaling, via TRPML1/calcineurin/TFEB pathway, that promotes lysosomal exocytosis and clearance of lysosomal accumulation in various cellular models of lysosomal storage disorders (LSDs). Here, we described methods to determine TFEB activation and lysosomal exocytosis that may represent innovative tools to study lysosomal function and to develop novel therapeutic approaches to promote clearance in LSDs.