Automated Family-Wide Annotation of Secondary Structure Elements

• DOI: 10.1007/978-1-4939-9161-7_3
• Publication Date: 2019-04-04T01:37:05Z
• Authors: Adam Midlik; Ivana Hutařová Va...; Jan Hutař; Taraka Ramji Moturu; Veronika Navrátilová; Jaroslav Koča; Karel Berka; Radka Svobodová V...
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Catalytic Domain; Amino Acid Motifs; Computational Biology; Proteins; Molecular Sequence Annotation; Algorithms; Software

Secondary structure elements (SSEs) are inherent parts of protein structures, and their arrangement is characteristic for each protein family. Therefore, annotation of SSEs can facilitate orientation in the vast number of homologous structures which is now available for many protein families. It also provides a way to identify and annotate the key regions, like active sites and channels, and subsequently answer the key research questions, such as understanding of molecular function and its variability.This chapter introduces the concept of SSE annotation and describes the workflow for obtaining SSE annotation for the members of a selected protein family using program SecStrAnnotator.