The role of neuromodulation of the hippocampus in the treatment of intractable complex partial seizures of the temporal lobe

• DOI: 10.1007/978-3-211-33081-4_36
• Publication Date: 2007-12-01T06:44:41Z
• Authors: Ana Luisa Velasco; F. Velasco; M. Velasco; F. Jiménez; J. D. Carrillo-Ruiz; G. Castro
• Keywords: Hippocampal sclerosis; Neuroradiology; Neuromodulation

We present the results of chronic electrical stimulation hippocampus (ESH) in 9 patients with complex partial seizures and at least 18 months follow-up. The magnetic resonance imaging (MRI) scan was normal 5 while 4 it showed hippocampal sclerosis. seizure frequency ranged from 10 to 50 per month. All were submitted implantation diagnostic 8-contact bilateral depth electrodes determine location epileptic foci. Once focus located, replaced by deep brain (DBS) electrodes. Following DBS, all improved. With respect outcome, divided two groups, one seizure-free (5 patients) other residual (4 patients). Both groups shared similar clinical features. However, who free had MRI those being stimulated on a sclerotic hippocampus. conclude that formation can control mesial temporal seizures. Best are obtained if we stimulate which does not show sclerosis MRI. In these cases, stopped recent memory tests improve even This result is extreme importance have either intractable or epileptogenic foci, excluded as candidates for lobectomy left no alternative.