Comparison of Intrathecal Dotarizine and Nimodipine Treatments in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study in Rabbits

• DOI: 10.1007/978-3-7091-0356-2_11
• Publication Date: 2011-06-10T13:29:25Z
• Authors: Mehmet Bulent Onal; Ilker Solmaz; Erdinc Civelek; Atilla Kircelli; Ozkan Tehli; Yusuf Izci; Ersin Erdogan; Engin Gonul
• Keywords: Nimodipine; Cerebral Vasospasm

Background: Cerebral vasospasm (CVS) is one of the most considerable complications subarachnoid hemorrhage (SAH). The aim this study was to assess and compare ability intrathecal dotarizine nimodipine prevent treat in a rabbit model hemorrhage. Method: Thirty male New Zealand white rabbits weighing 2,500–3,000 g were allocated into five groups randomly. treatment as follows: Control, only SAH, SAH/Dotarizine, SAH/Nimodipine, SAH/Vehicle. Forty-eight hours after SAH injection, all animals underwent femoral artery catheterization procedure by open surgery under anesthesia angiography performed for each animal fifth day just before sacrifice. Findings: Basilar vessel diameters are measured angiography. luminal sectional areas pathology slides. There statistically significant difference between mean basilar cross-sectional arterial wall thickness measurements control SAH-only (p < 0.05). Conclusions: These findings demonstrate that calcium channel blocker has marked vasodilatory effect an experimental rabbits. Nimodipine effect-proven agent CVS, but may take place it.