Comparison of Nimodipine Delivery Routes in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study in Rabbits

• DOI: 10.1007/978-3-7091-0356-2_5
• Publication Date: 2011-06-10T13:29:25Z
• Authors: Mehmet Bulent Onal; Erdinc Civelek; Atilla Kircelli; Ilker Solmaz; Sahin Ugurel; Firat Narin; Ilkay Isikay; Burcak Bilginer; Hakan Yakupoglu
• Keywords: Nimodipine; Cerebral Vasospasm; Neuroradiology

Background: Nimodipine is the most widely preferred and administered calcium channel blocker in cerebral vasospasm prevention treatment. There no experimental or clinical study investigating comparative effects of routine treatment modalities. Method: 35 male New Zealand White rabbits were assigned randomly to one seven groups: Control, only SAH, SAH/oral nimodipine, SAH/IV SAH/IT SAH/IA SAH/angiography. Findings: Basilar artery vessel diameters are measured by angiography. luminal sectional areas pathology slides. thicknesses significantly higher group 2 7 than others (p < 0.05). Luminal 5 6 other groups We found significant difference 1, > section 3 4 but lower 1. Conclusion: This first show effective drug delivery route CVS after SAH. useful. showed that selective IA nimodipine IT must be IV oral treatments chronic following