Chromosomes in acute leukemia

• DOI: 10.1007/bf00289443
• Publication Date: 2004-10-05T04:03:14Z
• Authors: E. L. Prigogina; E. W. Fleischman; G. P. Puchkova; O. E. Kulagina; S. A. Majakova; S. A. Balakirev; M. A. Frenkel; N. V. Khvatova; I. S. Peterson
• Keywords: Adult; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Genetic Markers; Male; 0301 basic medicine; Leukemia; Adolescent; Chromosomes, Human, 19-20; Infant; Middle Aged; Chromosome Banding; Leukemia, Lymphoid; 03 medical and health sciences; Child, Preschool; Chromosomes, Human, 21-22 and Y; Humans; Female; Chromosomes, Human, 4-5; Chromosome Deletion; Child; Aged

The karyotype of leukemic cells of 78 acute leukemia patients (37 ANLL, 34ALL, and 7 of unknown type) was studied by means of G-banding. Chromosomal abnormalities were found in 50 patients (72%). Chromosomes 8,21,5,7,11, and 19 were preferentially involved in the abnormalities, both in ANLL and in ALL. A high incidence of the characteristic rearrangement t(8;21) was noted in AML: (in 6 of 22 AMP patients). An identical reciprocal translocation--t(4;11)--was seen in 4 out of 34 ALL patients.