Assessment of anti-reserpine and anti-apomorphine activities of some psychic energizers in pigeons

• DOI: 10.1007/bf00401679
• Publication Date: 2004-11-09T01:15:29Z
• Authors: G. P. Gupta; R. C. Saxena; Om Chandra; K. N. Dhawan
• Keywords: Male; Imipramine; Reserpine; Apomorphine; Vomiting; Amitriptyline; Desipramine; Deanol; Antidepressive Agents; 3. Good health; Hydrazines; Orphenadrine; Animals; Female; Columbidae; Opipramol

Seven psychic energizers have been quantitatively evaluated for their antidepressant and tranquillizing activity using antagonism of reserpine induced emesis and apomorphine induced pecking in pigeons as test procedures for the two activities respectively. Pheniprazine and deanol possess anti-reserpine activity only whereas imipramine, desmethylimipramine, amitriptyline, opipramol and orphenadrine possess both anti-reserpine as well as anti-apomorphine activity. It is suggested that the two tests form a simple and reliable combination for evaluating potential antidepressants.