Marchiafava-Bignami disease: serial changes in corpus callosum on MRI

• DOI: 10.1007/bf00598954
• Publication Date: 2004-11-24T07:12:25Z
• Authors: K. H. Chang; S. H. Cha; M. H. Han; S. H. Park; D. L. Nah; J. H. Hong
• Keywords: Male; Neurologic Examination; Substance-Related Disorders; Middle Aged; Corpus Callosum; Alcoholism; 03 medical and health sciences; 0302 clinical medicine; Nerve Degeneration; Humans; Brain Damage, Chronic; Follow-Up Studies

Serial MRI findings of changes in corpus callosum lesions in two cases of Marchiafava-Bignami disease are presented. In both, MRI displayed diffuse swelling of the corpus callosum in the acute stage, thought to represent oedema and demyelination. In the chronic stage, in addition to atrophy of the corpus callosum with presumed focal necrosis, previously undescribed focal hypointensity on T2-weighted images, of unknown cause, was observed in the corpus callosum.